abstract：BACKGROUNDS AND AIMS:There is increasing evidence that gut-derived intraepithelial lymphocytes have potent cytolytic and immunoregulatory functions, which they use to sustain epithelial integrity. The aims of this study were to investigate the roles of small intestinal intraepithelial lymphocytes (SI-IELs) in oral tole...

journal_title：International journal of colorectal disease

authors： Ye Y,Yue M,Jin X,Chen S,Li Y

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:The impact of chemotherapy (CTx) on morbidity after liver resection for colorectal metastases (CRC-LM) has been increasingly investigated during recent years. Biologic agents like bevacizumab (BEV) or cetuximab (CET) are now added as "targeted therapy" (TT), also in neoadjuvant settings. Initial series could de...

journal_title：International journal of colorectal disease

authors： Neeff HP,Drognitz O,Klock A,Illerhaus G,Opitz OG,Hopt UT,Makowiec F

更新日期：2012-05-01 00:00:00

abstract：PURPOSE:Haemorrhoidal disease is one of the most common anorectal disorders. The aim of this study is to compare the results, over the last 10 years, of stapled haemorrhoidopexy (SH) with those of standard Milligan-Morgan haemorrhoidectomy (M&M). Furthermore, we discuss the proper indications for each technique in term...

journal_title：International journal of colorectal disease

authors： Panarese A,Pironi D,Vendettuoli M,Pontone S,Arcieri S,Conversi A,Romani AM,Filippini A

更新日期：2012-04-01 00:00:00

abstract：PURPOSE:This study aims to evaluate the role of colonic stenting as a bridge to surgery in acutely obstructed left-sided colon cancer. METHODS:Patients with acute left-sided malignant colonic obstruction with no evidence of peritonitis were recruited. After informed consent, patients were randomized to colonic stentin...

journal_title：International journal of colorectal disease

authors： Ho KS,Quah HM,Lim JF,Tang CL,Eu KW

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:The objectives of the study were to estimate the incidence and clarify the clinicopathologic feature of sporadic microsatellite instability (MSI)-high (MSI-H) colon cancer. Furthermore, the role of MSI in colon cancer prognosis was also investigated. METHODS:Microsatellite status was identified by genotyping. ...

journal_title：International journal of colorectal disease

authors： Lin CC,Lai YL,Lin TC,Chen WS,Jiang JK,Yang SH,Wang HS,Lan YT,Liang WY,Hsu HM,Lin JK,Chang SC

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Higher closure rates of the open abdomen have been reported with negative pressure wound therapy (NPWT) compared with other wound therapy techniques. However, the method has occasionally been associated with increased development of intestinal fistulae. The present study measures microvascular blood flow in the...

journal_title：International journal of colorectal disease

authors： Hlebowicz J,Hansson J,Lindstedt S

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Although the regional lymph node status is essential for staging of colorectal cancer, the importance of the total number of collected nodes remains controversial. Our aim was to examine the impact of the metastatic lymph node ratio (LNR) on the survival of patients with Dukes C colorectal cancer. METHODS:All ...

journal_title：International journal of colorectal disease

authors： Thomas M,Biswas S,Mohamed F,Chandrakumaran K,Jha M,Wilson R

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND AND STUDY AIMS:Computer-generated enhancements, which can highlight the surface and color of a colonic lesion, may be helpful to predict the histology; however, it remains unclear whether this technology can distinguish neoplastic from non-neoplastic colon polyps when the polyps are <1 cm without magnificati...

journal_title：International journal of colorectal disease

authors： Han ML,Lee YC,Chen CC,Fang YJ,Lee JY,Lin TL,Lin LW,Tseng PH,Wu MS,Wang HP

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:The purpose of this study was to prospectively compare rectal resection (RR) with colonic resection on sexual, urinary and bowel function and quality of life in both short-term and long-term. METHODS:Eighty-three patients who underwent RR were compared to 53 patients who underwent a colonic resection leaving t...

journal_title：International journal of colorectal disease

authors： Doeksen A,Gooszen JA,van Duijvendijk P,Tanis PJ,Bakx R,Slors JF,van Lanschot JJ

更新日期：2011-12-01 00:00:00

abstract：AIM:Evidence is lacking whether an abscess associated with anastomotic leak after an ileal pouch-anal anastomosis (IPAA) should be drained by transanal or CT-guided drainage. Therefore, the aim of this study was to compare outcomes after the two techniques for drainage. METHOD:Patients who underwent IPAA (1984-2009) a...

journal_title：International journal of colorectal disease

authors： Kirat HT,Remzi FH,Shen B,Kiran RP

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:The pathogenesis of rectal prolapse (RP) defined by a circumferential, full-thickness invagination of the rectal wall into the anal canal is controversial. RP is normally encountered in elderly women and attributed to several etiological factors (e.g., advanced age, pudendal nerve injury, laxity of supportin...

journal_title：International journal of colorectal disease

authors： Zorenkov D,Otto S,Böttner M,Hedderich J,Vollrath O,Ritz JP,Buhr H,Wedel T

更新日期：2011-11-01 00:00:00

abstract：PURPOSE:Kras mutations are negative predictors of anti-EGFR therapy, occurring in 40% of colorectal carcinomas (CRCs). Point substitutions in codon 12 or 13 are the most frequent mutations in Kras, but multiple mutations (MMs) in other codons can also develop. Few data exist on MMs with regard to their frequency and th...

journal_title：International journal of colorectal disease

authors： Macedo MP,Andrade Lde B,Coudry R,Crespo R,Gomes M,Lisboa BC,Aguiar S Jr,Soares FA,Carraro DM,Cunha IW

更新日期：2011-10-01 00:00:00

abstract：PURPOSE:Lymph node (LN) yield is a critical component of colon cancer staging and is often a surrogate for quality assessment in surgery. We investigated the impact of pathologists' training on LN harvest. METHODS:This is a retrospective review on 137 patients undergoing elective colectomy for adenocarcinoma at a sing...

journal_title：International journal of colorectal disease

authors： Bamboat ZM,Deperalta D,Dursun A,Berger DL,Bordeianou L

更新日期：2011-09-01 00:00:00

abstract：INTRODUCTION:Emergency right hemicolectomy has been associated with dismal outcome. But, data in Asians is lacking as pathologies that require emergency right hemicolectomy may differ from that in the Western population. The aims of our study were to review our institution's experience with emergency right hemicolectom...

journal_title：International journal of colorectal disease

authors： Tan KK,Liu JZ,Yeow Y,Gunasekaran S,Tan JJ

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:The main operative method in familial adenomatous polyposis (FAP) patients is restorative proctocolectomy with "J"-shaped pouch and temporary loop ileostomy. The aim of the study was the analysis of the frequency of the dysplasia and inflammation in the intestinal pouch and prognosis of the clinical course in F...

journal_title：International journal of colorectal disease

authors： Banasiewicz T,Marciniak R,Kaczmarek E,Krokowicz P,Paszkowski J,Lozynska-Nelke A,Gronek P,Plawski A,Drews M

更新日期：2011-09-01 00:00:00

abstract：PURPOSE:The aim of the study was to determine the spatiotemporal expression of Wnt5a during hindgut and anorectum development in human embryos and to explore the possible role of Wnt5a during the morphogenesis of the human hindgut and anorectum. MATERIALS AND METHODS:The embryos (n = 107) were sectioned serially and s...

journal_title：International journal of colorectal disease

authors： Li FF,Zhang T,Bai YZ,Yuan ZW,Wang WL

更新日期：2011-08-01 00:00:00

abstract：INTRODUCTION:When 'whole colonic imaging' is indicated, clinicians must decide between optical colonoscopy, barium enema and CT colonography (CTC). CTC is a relatively new technique which has become increasingly accessible in the UK over the past 5 years. As radiologists have gained experience and scanning parameters h...

journal_title：International journal of colorectal disease

authors： Almond LM,Bowley DM,Karandikar SS,Roy-Choudhury SH

更新日期：2011-08-01 00:00:00

abstract：PURPOSE:The diagnosis of irritable bowel syndrome is symptom based, and colonoscopy is the most direct way to rule out organic colonic diseases. It is controversial on the necessity of colonoscopy for patients with suspected irritable bowel syndrome and lacking alarm features. This study was designed to verify the orga...

journal_title：International journal of colorectal disease

authors： Gu HX,Zhang YL,Zhi FC,Jiang B,Huang Y

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:The RET protooncogene plays a crucial role in neural crest development; accordingly, mutations of RET cause MEN2A and familial medullary thyroid carcinoma, while the expression deregulation of RET is involved in the pathophysiology of glioblastoma multiforme (GBM) and pancreatic cancer (PDAC). The aim of this s...

journal_title：International journal of colorectal disease

authors： Rückert F,Görgens H,Richter I,Krex D,Schackert G,Kuhlisch E,Fitze G,Saeger HD,Pilarsky C,Grützmann R,Schackert HK

更新日期：2011-07-01 00:00:00

abstract：PURPOSE:Published multigene classifiers suggesting outcome prediction for patients with stage UICC II colon cancer have not been translated into a clinical application so far. Therefore, we aimed at validating own and published gene expression signatures employing methods which enable their reconstruction in routine di...

journal_title：International journal of colorectal disease

authors： Gröne J,Lenze D,Jurinovic V,Hummel M,Seidel H,Leder G,Beckmann G,Sommer A,Grützmann R,Pilarsky C,Mansmann U,Buhr HJ,Stein H,Hummel M

更新日期：2011-07-01 00:00:00

abstract：INTRODUCTION:It is generally believed that resumption of feeding after colorectal resection is indicated only after recovery of bowel function. This study was designed to verify safety, feasibility, and tolerance of early oral postoperative feeding (EOF) outside an enhanced recovery after surgery (ERAS) program. MATER...

journal_title：International journal of colorectal disease

authors： Gianotti L,Nespoli L,Torselli L,Panelli M,Nespoli A

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:Neoplasia cells exfoliated from colorectal epithelium have dysfunctional apoptotic mechanisms, thus it is possible to identify high-molecular weight DNA fragments in feces. This prospective single-center study was performed to evaluate the sensitivity and specificity of fecal-based DNA integrity versus immunolo...

journal_title：International journal of colorectal disease

authors： Kalimutho M,Del Vecchio Blanco G,Cretella M,Mannisi E,Sileri P,Formosa A,Pallone F,Federici G,Bernardini S

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND/AIM:In order to define future chemoprevention strategies for adenomas or carcinomas in the pouch of patients with familial adenomatous polyposis (FAP), a 4-weeks intervention with (1) sulindac, (2) inulin/VSL#3, and (3) sulindac/inulin/VSL#3 was performed on 17 patients with FAP in a single center interventi...

journal_title：International journal of colorectal disease

authors： Friederich P,Verschuur J,van Heumen BW,Roelofs HM,Berkhout M,Nagtegaal ID,van Oijen MG,van Krieken JH,Peters WH,Nagengast FM

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who nor...

journal_title：International journal of colorectal disease

authors： Courtney ED,Brennan M,Noble-Jamieson G,Heuschkel R,Davies RJ

更新日期：2011-03-01 00:00:00

abstract：AIM:Sacral nerve stimulation (SNS) has recently been used in the management of faecal incontinence (FI). This study compared SNS to conservative management with regards to functional and quality of life outcomes. METHODS:Meta-analysis of studies published between 1995 and 2008 on SNS for FI was performed. Outcomes eva...

journal_title：International journal of colorectal disease

authors： Tan E,Ngo NT,Darzi A,Shenouda M,Tekkis PP

更新日期：2011-03-01 00:00:00

abstract：PURPOSE:The aim of this study is to evaluate the influence of germline vascular endothelial growth factor (VEGF) gene polymorphisms (VGPs) on the efficacy of the anti-VEGF antibody bevacizumab (Bev) in metastatic colorectal cancer (MCRC) patients. METHODS:Forty MCRC patients eligible for a first-line therapy were enro...

journal_title：International journal of colorectal disease

authors： Formica V,Palmirotta R,Del Monte G,Savonarola A,Ludovici G,De Marchis ML,Grenga I,Schirru M,Guadagni F,Roselli M

更新日期：2011-02-01 00:00:00

abstract：PURPOSE:The ideal timing for patients with colorectal cancer to undergo surgery for resectable synchronous liver metastases remains under debate. We describe a new sequential approach using laparoscopic/robotic surgery for the treatment of synchronous liver metastases. METHODS:A 73-year-old man presented with sigmoid ...

journal_title：International journal of colorectal disease

authors： Giulianotti PC,Giacomoni A,Coratti A,Addeo P,Bianco FM

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:There is strong evidence supporting the importance of the volume-outcome relationship with respect to lung and pancreatic cancers. This relationship for rectal cancer surgery however remains unclear. We review the currently available literature to assess the evidence base for volume outcome in relation to recta...

journal_title：International journal of colorectal disease

authors： Nugent E,Neary P

更新日期：2010-12-01 00:00:00

abstract：PURPOSE:Use of biosutures in animal models of colonic anastomoses is associated with decreased adhesions without affecting anastomotic strength. This study aimed to evaluate the effect of biosutures on colonic anastomoses kept free of adhesions by peritoneal instillation of icodextrin 4%. METHODS:Three types of coloni...

journal_title：International journal of colorectal disease

authors： Pascual I,Fernández de Miguel G,García Arranz M,García-Olmo D

更新日期：2010-12-01 00:00:00

abstract：AIM:Transcutaneous electrical nerve stimulation (TENS) is a possible alternative to sacral nerve stimulation because the neurophysiologic targets might be similar but the former method is non-invasive and cheaper. The aim of the study was to assess both symptom and quality of life (QoL) improvements in patients sufferi...

journal_title：International journal of colorectal disease

authors： Eléouet M,Siproudhis L,Guillou N,Le Couedic J,Bouguen G,Bretagne JF

更新日期：2010-09-01 00:00:00

abstract：PURPOSES:Carcinoids are heterogeneous neuroendocrine tumors with malignant potential. The rectum is the third most common location for gastrointestinal carcinoids. We assessed the clinicopathological characteristics of rectal carcinoids. METHODS:A retrospective study of 203 patients treated for rectal carcinoids at th...

journal_title：International journal of colorectal disease

authors： Yoon SN,Yu CS,Shin US,Kim CW,Lim SB,Kim JC

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:The functional outcome and quality of life after sphincter-saving operations for ulcerative colitis have not been previously assessed in Indian patients whose dietary habits and socio-cultural practices differ considerably from those in western countries. PATIENTS AND METHODS:Between 1996 and 2002, we perfo...

journal_title：International journal of colorectal disease

authors： Somashekar U,Gupta S,Soin A,Nundy S

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate prospectively the functional outcome of posterior sagittal rectopexy with prolene mesh for rectal prolapse in young adults. PATIENTS AND METHODS:The study was carried out on 32 patients, 21 were males (65.63%) presented with complete rectal prolapse with a mean age of 3...

journal_title：International journal of colorectal disease

authors： Kosba Y,Elshazly WG,Abd El Maksoud W

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The introductions of total mesorectal excision and double-stapling technique into colorectal surgery have promoted the clinical application of sphincter preservation. However, for the tumors localized on the middle or lower level of rectum, sphincter-preservation approaches might be problematic in some patients...

journal_title：International journal of colorectal disease

authors： Han F,Li H,Zheng D,Gao H,Zhang Z

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:Constipation is frequently seen in patients with mental retardation (MR). Its pathophysiology is poorly understood. Measurement of colon transit time (CTT) differentiates between retentive and non-retentive constipation. AIM:To determine total and segmental CTT in MR patients compared to healthy controls....

journal_title：International journal of colorectal disease

authors： Vande Velde S,Van Biervliet S,Van Goethem G,De Looze D,Van Winckel M

更新日期：2010-07-01 00:00:00

abstract：PURPOSE:The aim of the present study was to investigate the characteristics of patients who developed delayed anastomotic leakage (DAL) following sphincter-preserving surgery for rectal cancer. We evaluated the following factors: (1) the incidence of DAL, (2) the clinical features of patients who developed DAL, (3) the...

journal_title：International journal of colorectal disease

authors： Shin US,Kim CW,Yu CS,Kim JC

更新日期：2010-07-01 00:00:00

abstract：:Epidemiological studies provide strong evidence to confirm the correlation between cigarette smoking and inflammatory bowel diseases. This relationship is proved to be positive in Crohn's disease and negative in ulcerative colitis. What in smoking alters the course of inflammatory bowel diseases is still a mystery. Di...

journal_title：International journal of colorectal disease

authors： El-Tawil AM

更新日期：2010-06-01 00:00:00

abstract：PURPOSE:Surgical site infections (SSI) cause excess morbidity and mortality in modern surgery. Several different approaches to reduce the incidence of SSI have been investigated with variable results. METHOD:This is to our knowledge the first systematic randomized evaluation in patients undergoing laparotomy in viscer...

journal_title：International journal of colorectal disease

authors： Baier PK,Glück NC,Baumgartner U,Adam U,Fischer A,Hopt UT

更新日期：2010-05-01 00:00:00

abstract：PURPOSE:Improved survival in patients with stage III colon cancer after a laparoscopic colectomy (LC) has been reported by Lacy et al. (Lancet 359:2224-2229, 6), and preserved immunity was suggested as the reason for the survival advantage. The aim of our study was to clarify the existence of an immunological benefit a...

journal_title：International journal of colorectal disease

authors： Han SA,Lee WY,Park CM,Yun SH,Chun HK

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIMS:A 5-bp insertion-deletion (indel) polymorphism in the promoter of interferon regulatory factor 5 (IRF5) has been associated with inflammatory bowel diseases (IBD). This polymorphism generates an additional binding site for the transcription factor SP1 and has been shown to augment the expression of ...

journal_title：International journal of colorectal disease

authors： Balasa A,Gathungu G,Kisfali P,Smith EO,Cho JH,Melegh B,Kellermayer R

更新日期：2010-05-01 00:00:00